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CORONARY DISEASE REVERSAL

Promogranate

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Halting progress of severe aortic valve stenosis (AVS) by extensive lifestyle modification
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  • POMEGRANATE

    Pomegranate, beside preventing and reversing CAD, also prevents cancer, and promote healthy skin by its powerful abundant antioxidant punicalagins

    • Pomegranate increases the synthesis of nitric oxide, required for healthy arterial endothelial function,
    • protect nitric oxide from oxidative degradation,
    • reduces coronary plaque buildup,
    • reverses atherosclerosis,
    • inhibits LDL oxidation,
    • reduces blood pressure, and
    • oxidative stress.

      Nineteen patients from the Vascular Surgery Clinic in Haifa, Israel, were selected to participate in this three-year trial.

      19 subjects between age 65 and 75, with 70-90% asymptomatic carotid artery stenosis. Ten subjects consumed 50 ml of pomegranate juice daily.
      The other nine control group received a placebo drink and continued their on going drug regimens. All had similar diet and lifestyles during the trial.


After three months, in the treated group had an average carotid artery thickness declined by 13%, and 35% after 12 months from baseline.

The average thickness of the carotid artery among the placebo group increased by 9% after 12 months.
The peak systolic velocity of the blood in the carotid arteries fell, and systolic blood pressure dropped by 21% after 12 months.
All desired laboratory investigations of the treated group stayed unchanged.

Total antioxidant blood level increased by 130% and serum paraoxonase-1 by 83% after 12 months. Paraoxonase-1 can reduce harmful lipid peroxides in arterial cells and in lipoproteins in atherosclerotic lesions, and helps break up of existing plaques.

LDL need to be oxidized before it can adhere to the arterial wall and damage it. Lipid peroxidation was reduced by 59% after 12 months among treated group
Treated group had LDL oxidation initiation time, increased from 30 minutes to 65 minutes after 12 months.

Delays in oxidation and increased antioxidants in the blood prevent new plaque build up.


16% further reduction in lipid peroxidation at 36 months.
Pomegranate is required to continue to maintain the improvement. 9-11

50 ml pomegranate daily reduces both systolic blood pressure by 5% and serum angiotensin converting enzyme (ACE) activity byb 36% after only two weeks.
ACE activity helps to prevent atherosclerosis independent of its effects on blood pressure,12


l
Location
Haifa, Israel
2000
Criteria

Treated
Control group with similar parameter
Subjects number
10
9
Drink 50 ml daily
Pomegranate 50 ml daily
Placebo drink 50 ml
Age
65-70
65-70
Asymptomatic carotid artery stenosis
70-90%
70-90%
Three months later carotid artery thickness from base line
Declined by 13%
-

Carotid artery thickness after 12 months from baseline

Declined 35%
Increased by 9%
The peak systolic velocity of the blood in the carotid arteries after 12 months.
Fell
-
Systolic blood pressure
Dropped by 21%
Add your content here
Systolic blood pressure
Dropped by 21%
Add your content here
Systolic blood pressure
Dropped by 21%
Add your content here

All standard laboratory investigation

Unchanged

-

Total antioxidant blood level
after 12 months.

Increased by 130%

-

Total serum paraoxonase-1
It can reduce harmful lipid peroxides in arterial cells and in lipoproteins in atherosclerotic lesions, and helps break up of existing plaques.

Increased by 83%

-

Lipid peroxidation after 12 months
LDL need to be oxidized before it can adhere to the arterial wall and damage it.

Reduced by 59%

-

LDL oxidation initiation time after 12 months.

Increased from 30 minutes to 65 minutes.

Add your content here

Lipid peroxidation at 36 months.
.
Pomegranate is required to continue to maintain the improvement

16% further reduction.

Add your content here

DIFFERENT STUDY
50 ml pomegranate daily
for two weeks


Reduces systolic blood pressure by 5%.

-

50 ml pomegranate daily for two weeks and an serum angiotensin converting enzyme (ACE)

ACE activity helps to prevent atherosclerosis independent of its effects on blood pressure.

Reduces by 36%.

Add your content here

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Pomegranate juice for atherosclerosis
Pomegranate juice appears to be beneficial in reducing oxidation of lipids and may reduce the risk for atherosclerosis.

Anti-oxidative effects of pomegranate juice consumption by diabetic patients on serum and on macrophages.
Atherosclerosis. 2006.
"We thus conclude that pomegranate juice consumption by diabetic patients did not worsen the diabetic parameters, but rather resulted in anti-oxidative effects on serum and macrophages, which could contribute to attenuation of atherosclerosis development in these patients."

Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease.
Am J Cardiol. 2005. The Preventive Medicine Research Institute, Sausalito, California, USA.
"In conclusion, daily consumption of pomegranate juice may improve stress-induced myocardial ischemia in patients who have coronary heart disease."

-

PATENTS:

http://www.google.com/patents?hl=en&lr=&vid=USPAT6641850&id=vqQNAAAAEBAJ&oi=fnd&dq=pomegranate+patent,+Aviram+M,&printsec=abstract#v=onepage&q&f=false

"Patent: Active ingredient/s of pomegranate is/are isplated and patened.POMELLAŽ Gains Two More U.S. Patents. Patents include applications covering the composition and methodology of POMELLAŽ."

http://www.vs-corp.com/USPTO-Grants-Two-More-US-Patent.news

===

Pomegranate PowerŽ Extract Granted Patent EP
Patent Number 1721532 B1

"Murrieta, California – Monday April 6, 2009 - European Union - “EPO” has awarded Collagen Nutraceuticals, Inc., Patent for the advanced extraction method utilized in manufacturing Pomegranate PowerŽ Extract."

http://www.collagennutra.com/press-pom-power.htm


References:
9. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.
10. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BV. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest. 1998 Apr 15;101(8):1581-90.
11. Aviram M, Hardak E, Vaya J, et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation. 2000 May 30;101(21):2510-7.
12. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.

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