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POMEGRANATE
Pomegranate, beside preventing and reversing CAD, also prevents cancer, and promote healthy skin by its powerful
abundant antioxidant punicalagins
- Pomegranate increases the synthesis of nitric oxide, required for healthy arterial endothelial function,
- protect nitric oxide from oxidative degradation,
- reduces coronary plaque buildup,
- reverses atherosclerosis,
- inhibits LDL oxidation,
- reduces blood pressure, and
- oxidative stress.
Nineteen patients from the Vascular Surgery Clinic in Haifa, Israel,
were selected to participate in this three-year trial.
19 subjects between
age 65 and 75, with 70-90% asymptomatic carotid artery stenosis. Ten subjects consumed 50 ml of pomegranate juice daily.
The
other nine control group received a placebo drink and continued their on going drug regimens. All had similar diet and lifestyles
during the trial.
After three months, in the treated group had an average carotid artery thickness declined by 13%, and 35% after 12 months
from baseline.
The average thickness of the carotid artery among the placebo group increased by 9% after 12 months.
The
peak systolic velocity of the blood in the carotid arteries fell, and systolic blood pressure dropped by 21% after 12 months.
All
desired laboratory investigations of the treated group stayed unchanged.
Total antioxidant
blood level increased by 130% and serum paraoxonase-1 by 83% after 12 months. Paraoxonase-1 can reduce harmful
lipid peroxides in arterial cells and in lipoproteins in atherosclerotic lesions, and helps break up of existing plaques.
LDL need to be oxidized before it can adhere to the arterial wall
and damage it. Lipid peroxidation was reduced by 59%
after 12 months among treated group
Treated group had LDL oxidation initiation time, increased from 30 minutes to 65 minutes
after 12 months.
Delays in oxidation and increased
antioxidants in the blood prevent new plaque build up.
16% further reduction
in lipid peroxidation at 36 months.
Pomegranate is required to continue to maintain the improvement. 9-11
50 ml
pomegranate daily reduces both systolic blood pressure by 5% and serum angiotensin converting enzyme (ACE) activity byb 36% after only two weeks.
ACE activity helps to prevent atherosclerosis independent of
its effects on blood pressure,12
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Control group with similar parameter |
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Asymptomatic carotid artery stenosis |
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Three months later carotid artery thickness from base line |
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Carotid artery thickness after 12 months from baseline |
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The peak systolic velocity of the blood in the carotid arteries after 12 months. |
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All standard laboratory investigation |
Unchanged |
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Total antioxidant blood level
after 12 months.
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Increased by 130%
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Total serum
paraoxonase-1
It can reduce harmful lipid peroxides in arterial cells and in lipoproteins in atherosclerotic
lesions, and helps break up of existing plaques.
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Increased by
83%
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Lipid
peroxidation after 12 months
LDL need to be oxidized before it can adhere to the arterial
wall and damage it.
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Reduced
by 59%
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LDL oxidation initiation time after 12 months.
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Increased from 30 minutes to 65 minutes. |
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Lipid peroxidation at 36 months.
.
Pomegranate is required to continue to maintain the improvement |
16% further reduction. |
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DIFFERENT STUDY
50 ml pomegranate daily
for two weeks
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Reduces systolic blood pressure by 5%.
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50 ml pomegranate daily for two weeks and an serum angiotensin
converting enzyme (ACE)
ACE activity helps to prevent atherosclerosis independent of its effects on blood pressure.
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Reduces by 36%.
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Pomegranate juice for atherosclerosis
Pomegranate juice appears to be beneficial in reducing oxidation
of lipids and may reduce the risk for atherosclerosis.
Anti-oxidative effects of pomegranate juice consumption by diabetic patients on serum and on macrophages.
Atherosclerosis.
2006.
"We thus conclude that pomegranate juice consumption by diabetic patients did not worsen the diabetic parameters,
but rather resulted in anti-oxidative effects on serum and macrophages, which could contribute to attenuation of atherosclerosis
development in these patients."
Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease.
Am
J Cardiol. 2005. The Preventive Medicine Research Institute, Sausalito, California, USA.
"In conclusion, daily consumption
of pomegranate juice may improve stress-induced myocardial ischemia in patients who have coronary heart disease."
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PATENTS:
http://www.google.com/patents?hl=en&lr=&vid=USPAT6641850&id=vqQNAAAAEBAJ&oi=fnd&dq=pomegranate+patent,+Aviram+M,&printsec=abstract#v=onepage&q&f=false
"Patent: Active ingredient/s of pomegranate is/are isplated and patened.POMELLAŽ Gains Two More U.S. Patents. Patents include
applications covering the composition and methodology of POMELLAŽ."
http://www.vs-corp.com/USPTO-Grants-Two-More-US-Patent.news
===
Pomegranate PowerŽ Extract Granted Patent EP
Patent Number 1721532
B1
"Murrieta, California – Monday April 6, 2009 - European Union - “EPO” has awarded
Collagen Nutraceuticals, Inc., Patent for the advanced extraction method utilized in manufacturing Pomegranate PowerŽ Extract."
http://www.collagennutra.com/press-pom-power.htm
References:
9. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid
artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.
10.
Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BV. Paraoxonase inhibits high-density lipoprotein oxidation
and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest. 1998 Apr 15;101(8):1581-90.
11.
Aviram M, Hardak E, Vaya J, et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary
and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation. 2000 May 30;101(21):2510-7.
12.
Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic
blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8.
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