Reduce most grains and sugars of any form except complex from diet. This will lower sugar level which lead to
lower insulin and leptin levels. Elevated insulin and leptin levels produce inflammatory prostaglandin production and pain.
Hot and cold packs
ANIMAL AND VEGETABLES
Omega-3 fat like krill oil contain fats EPA and DHA to have anti-inflammatory properties.
Astaxanthin: A caretenoid, oil-soluble antioxidants beside antiinflammatory. It is often more effective than
NSAIDs though may need high doses.
The yellows, reds, and orange color to salmon, flemingo, fruits, vegitable and folages are due to the presence
of carotenoids and are being unmasked by the disappearance of chlorophyll
Cetyl Myristoleate (CMO): An oil in fish, dairy and butter, acts as a "joint lubricant" and an anti-inflammatory.
Pineapple (Bromelain content)
HERBS, PLANTS AND SPICES
Lolot (Piper lolot)
Capsicum (hot peppers)
Cayenne Cream (capsaicin cream): It refuces the substance P, a chemical component of nerve, thus transmission of pain
signals to brain.
A potent anti-inflammatory agent and has the ability to reduce Tylenol-associated adverse health
Bromelain: A protein-digesting enzyme, found with in the core of pineapples.
Boswellia (Boswellin or "Indian frankincense")
A herb with powerful anti-inflammatory properties known for thousands of years.
Evening Primrose, Black Currant and Borage Oils: They contain anti inflammatory fatty acid gamma linolenic acid
|Yoon-Young Sung. Antiplatelet, anticoagulant and
fibrinolytic effects of Litchi chinensis Sonn. extract. |
|Published online on:
Thursday, December 22, 2011.|
Litchi chinensis Sonn. (lychee), a fruit from a subtropical evergreen tree, cultivated throughout Southeast
Asia, particularly in China. It has been reported to have anti-inflammatory, antioxidant and antidiabetic activities.
This study was performed wuith a 70% ethanol extract from lychee on rats.
It did dose-dependently inhibited collagen- and ADP-induced platelet aggregation in platelet-rich plasma.
It also significantly prolonged coagulation times.
It increased fibrinolytic activity in a dose-dependent manner.
These results demonstrated the antithrombotic effects of LCE and suggest that Litchi chinensis may be a new
natural source for the development of antiplatelet, anticoagulant and thrombolytic therapeutics for thrombotic and cardiovascular
Affiliations: Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Yuseong-gu,
Daejeon 305-811, Republic of Korea
"Both in vitro incubation and oral supplementation with PGJ decrease platelet aggregation, increase platelet-derived
NO release, and decrease superoxide production."1. This is also confirmed by other study.2
1. Freedman JE. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release.
Circulation. 2001 Jun 12;103(23):2792-8.
2. Keevil JG. et al . Grape juice, but not orange juice or grapefruit juice, inhibits human
platelet aggregation. J Nutr. 2000 Jan;130(1):53-6
Flow-mediated vasodilation (FMD)
James H. Stein etal. Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility
of .LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease. Circulation. 1999;100:1050-1055
15 adults with CAD (angiographically documented) drank (body weight adusted amount) of purple grape juice for 14
a) Flow-mediated vasodilation (FMD): This is a standard technique that measures brachial artery blood flow by using
b) Susceptibility of LDL particles to oxidation was also determined by using standadr method.
FMD ( endothelium-dependent vasodilatation) was improved and LDL susceptibility to oxidation was reduced, most likely
due to flavonoids in purple grape products, independent of alcohol content.
Lolot (Piper lolot)
It is a flowering vine , cultivated for its leaf which is used in Lao and Vietnamese cuisine as a flavoring wrap for grilling meats. It is introduced to the United States by Lao and Vietnamese emigrants. It is
used to relieve symptoms from inflammation to snakebites.1
"The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation
induced by arachidonic acid (AA) and platelet activating factor (PAF).." in rats.
1. Wikipedia. http://en.wikipedia.org/wiki/Lolot
2. Chia-Ying Li.olation and Identification of Antiplatelet Aggregatory Principles from
the Leaves of Piper lolot. J. Agric. Food Chem., 2007,
55 (23), pp 9436–9442. DOI: 10.1021/jf071963l
References:Chiropractors and Exercise Are Better than Drugs Says New Study
EXTRA VIRGIN OLIVE OIL (EVOO)
The first pressed, without chemical treatments and extracted directly from the olive
fruit by grinding, what is known as “cold pressed".
The best olive oil is organic cold pressed, extra virgin olive
Extra virgin olive oil (EVOO) obtained from the first pressing provides the anti-inflammatory benefits of the oil.
EVOO contains phytonutrients, especially polyphenols, which are anti-inflammatory.
Mediterranean diet containing olive oil decreases the risk of heart disease. Olive oil containing polyphenols hydroxytyrosol
(HT) - helps protect the cells that line blood vessels from being damaged by oxidative process.
Mechanism of protection of vessels by olive oil:
HT triggers changes at a genetic level in the vessel cells to enhance their antioxidant defense system. Olive oil
also contains antioxidants vitamin E and beta-carotene. Olive oil also provides our blood vessels with unique molecules
like HT that actually work at a genetic level to help the cellular walls of the blood vessels remain strong.
Olive oil has long been recognized for its unusual fat content. This plant oil is one of the few widely used culinary
oils that contains about 75% of its fat in the form of oleic acid (a monounsaturated, omega-9 fatty acid). In terms of monounsaturated
fat, the closest common culinary oil to olive is canola oil, with about 60% of its fat coming in monounsaturated form. By
contrast, the fat in soybean oil in only 50-55% monounsaturated; in corn oil, it's about 60%; in sunflower oil, about 20%;
and in safflower oil, only 15%. When diets low in monounsaturated fat are altered to increase the monounsaturated fat content
(by replacing other oils with olive oil), research study participants tend to experience a significant decrease in their total
blood cholesterol, LDL cholesterol, and LDL:HDL ratio. Recent research studies have taken these heart-healthy effects of olive
oil one step further. Olive oil's monounsaturated fat content (specifically, its high level of oleic acid) has now been determined
to be a mechanism linking olive oil intake to decreased blood pressure. Researchers believe that the plentiful amount of oleic
acid in olive oil gets absorbed into the body, finds its way into cell membranes, changes signaling patterns at a cell membrane
level (specifically, altering G-protein associated cascades) and thereby lowers blood pressure. To our knowledge, this is
the first time that the monounsaturated fat content of olive oil has been linked not only to cholesterol reduction, but also
to reduction of blood pressure.
Olive oil contains monounsaturated fatty acids (MUFAs), ? a healthy dietary fat.
Polyunsaturated fats are (PUFAs).
MUFAs may also help normalze blood clotting.
And some research shows that MUFAs may also benefit insulin levels and blood sugar control, which can be especially helpful
if you have type 2 diabetes.
Also, be aware that heat, light and air can affect the taste of olive oil and possibly its health-promoting nutrients.
Store olive oil in a dark, room-temperature cupboard, or even in the refrigerator. The fats and healthy phytonutrients in
olive oil — as well as the taste — can slowly degrade over time, so it's probably best to use it within a year
or within six months once opened
Olive oil: What are the health benefits?If olive oil is high in fat, why is it considered healthy?Answer
from Donald Hensrud, M.Dhttp://www.mayoclinic.com/health/food-and-nutrition/AN01037
Olive oil, extra virgin
The George Mateljan Foundation
extra virgin olive oil (EVOO) obtained from the first pressing of the oil to the anti-inflammatory benefits
of virgin olive oils (non-EVOO) obtained from later pressings. What researchers found was an ability of EVOO to lower inflammatory
markers in the blood when non-EVOOs were unable to do so. (Study measurements included blood levels of thromboxane A2, or
TXA2, and leukotriene B2, or LBT2.) This ability of extra virgin olive oil to help protect against unwanted inflammation is
not surprising, since EVOO is known to contain stronger concentrations of phytonutrients (especially polyphenols) that have
well-known anti-inflammatory properties.
*Not even olive oil (monounsaturated), explained by Dr.
Esselstyn in the video below. Long and short term study show that there is no difference in CAD progression between olive
oil and other monounsaturated oil and saturated oil such as butter. Beside, olive oil also implied as causative factor for
"NO OIL! Not even olive oil, which goes against a lot of other advice out there about so-called good fats.
The reality is that oils are extremely low in terms of nutritive value. They contain no fiber, no minerals and are 100% fat
calories. And above all they contain saturated fat which immediately injures the endothelial lining of the arteries when eaten.
It doesn't matter whether it's olive oil, corn oil, or any other kind of oil. You should not consume any oil if you have heart
disease. This is so important I have detailed oil in Chapter 10"32
Stem of Spatholobus suberectu (SSE)
The vine stem of Spatholobus suberectu (SSE) showed antiplatelet activity without anticoagulant effects
mainly through the inhibition of fibrinogen binding to the GP IIb/IIIa receptor. SSE is used for the treatment of diseases
related to blood stasis syndrome in traditional medicine in Korea, Japan, and China.
. Antiplatelet effects of Spatholobus suberectus via inhibition of the glycoprotein IIb/IIIa receptor. J Ethnopharmacol.
2011 Mar 24;134(2):460-7.
Anti atherosclerosis and heart disease. Garlic contains allicin and ajoene, which act to prevent
blood platelets from sticking together and forming clots (the University of Michigan Health System).
In addition to its antiplatelet actions, garlic also lowers cholesterol and blood pressure,
which are all important to cardiovascular health, notes the University of Pittsburgh Medical Center.
A study published in 1991 found that garlic reduced platelet aggregation, or "stickiness,"
in humans, the University of Michigan notes.
Ginger inhibits the induction of several gene encoding cytokines, chemokines, and the inducible enzyme
cyclooxygenase-2, involved in the chronic inflammatory response.1
A study published in the November 2003 issue of Life Sciences suggests that at least one reason for ginger�s beneficial
effects is the free radical protection afforded by one of its active phenolic constituents, 6-gingerol. In this in vitro
(test tube) study, 6-gingerol was shown to significantly inhibit the production of nitric oxide, a highly reactive nitrogen
molecule that quickly forms a very damaging free radical called peroxynitrite. Another study appearing in the November 2003
issue of Radiation Research found that in mice, five days treatment with ginger (10 mg per kilogram of body weight)
prior to exposure to radiation not only prevented an increase in free radical damage to lipids (fats found in numerous bodily
components from cell membranes to cholesterol), but also greatly lessened depletion of the animals� stores of glutathione,
one of the body�s most important internally produced antioxidants.
A study published in the February 2005 issue of the Journal of Alternative and Complementary Medicine
sheds further light on the mechanisms of action that underlie ginger's anti-inflammatory effectiveness. In this research,
ginger was shown to suppress the pro-inflammatory compounds (cytokines and chemokines) produced by synoviocytes (cells comprising
the synovial lining of the joints), chrondrocytes (cells comprising joint cartilage) and leukocytes (immune cells).
Grzanna R, Lindmark L, Frondoza CG. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005 Summer;8(2):125-32.
Performing your original search, ginger anti inflammatory, in PubMed will
retrieve 166 records
Akoachere JF, Ndip RN, Chenwi EB et al. Antibacterial effect of Zingiber officinale and Garcinia kola on respiratory tract
pathogens. East Afr Med J. 2002 Nov;79(11):588-92 2002.
Bode A. Ginger is an effective inhibitor of HCT116 human colorectal carcinoma in vivo. paper presented at the Frontiers
in Cancer Prevention Research Conference, Phoenix, AZ, Ocbober 26-3-, 2003 2003.
Borrelli F, Capasso R, Aviello G, Pittler MH, Izzo AA. Effectiveness and safety of ginger in the treatment of pregnancy-induced
nausea and vomiting. Obstet Gynecol. 2005 Apr;105(4):849-56. 2005. PMID:15802416.
Ficker CE, Arnason JT, Vindas PS et al. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts.
Mycoses. 2003 Feb;46(1-2):29-37 2003.
Fischer-Rasmussen W, Kjaer SK, Dahl C, et al. Ginger treatment of hypereesis gravidarum. Eur J Obstet Gynecol Reprod Biol
Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. -Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse
macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003 Nov 14;73(26):3427-37. 2003.
Kiuchi F, et al. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm
Bull 40 (1992):387-91 1992.
Nature Immunology Online. Nature Immunology Online. 2001;10.1038/ni732 2001.
Phan PV, Sohrabi A, Polotsky A, Hungerford DS, Lindmark L, Frondoza CG. Ginger extract components suppress induction of
chemokine expression in human synoviocytes. J Altern Complement Med. 2005 Feb;11(1):149-54. 2005. PMID:15750374.
Rhode JM, Huang J, Fogoros S, Tan L, Zick S, Liu JR. Ginger induces apoptosis and autophagocytosis in ovarian cancer cells.
Abstract #4510, presented April 4, 2006 at the 97th AACR Annual Meeting, April 1-5, 2006, Washington, DC. 2006.
Taking ginkgo biloba may help to thin your blood by preventing excessive blood platelet coagulation.
Ginkgo appears to inhibit the platelet activating factor, or "PAF," which is a chemical that encourages your blood to coagulate
and form clots, explains the University of Michigan Health System. A 1990 controlled clinical trial in Germany found that
ginkgo effectively reduced excessive blood platelet coagulation.
Turmeric can also act like antiplatelet medications and reduce your blood's tendency to form
clots. Several studies have suggested that turmeric may be effective in preventing atherosclerosis, notes the University of
Pittsburgh Medical Center. According to a report published in 1985, turmeric's active constituent, curcumin, was shown in
animal studies to have antiplatelet effects, says the University of Michigan Health System. A preliminary medical study published
in 1995 found that curcumin stops platelet aggregation in humans as well.
Peony and bilberry have also shown antiplatelet effects similar to turmeric, the University
of Michigan adds.
The “Drug Monograph” lists numerous herbs you should not take when you take Plavix because
all of these herbs are also antiplatelets. They include alfalfa, dong quai, guggul, bromelain, garlic, prickly ash, cat's
claw, ginger, sweet clover, bladderwrack, feverfew, licorice, coleus, grape seed, SAMe, cordyceps, green tea, chamomile, ginkgo
biloba, reishi, evening primrose oil, horse chestnut seed, white willow, fenugreek, horseradish, anise, ginseng, turmeric,
bilberry and red clover.
- angelica root, anise, arnica flower, asafoetida, bogbean, boldo,
- Bromelain - Herbs with Anti-platelet properties.
- capsicum, celery, chamomile,
- clove - Herbs with Anti-platelet properties.
- danshen, fenugreek, feverfew, fish oil,
- garlic - It has been indicated that when essential garlic oil was mixed with blood samples from healthy individuals, cells
were less likely to clump together (coagulate) in a laboratory setting. Although there had been no documented reports of any
serious interaction effects when taking both Coumadin and garlic, studies had implied that a serious reaction might be possible.
- ginger - Traditionally, ginger (Zingiber officinale) has been taken to curb motion sickness and arthritis. Today, it has
been reported to reduce blood clotting.
- ginkgo - Ginkgo leaf has been shown to decrease platelet aggregation. It is thought that the ginkgo constituent, ginkgolide
B, displaces platelet-activating factor from its binding sites, decreasing blood coagulation (6048).
- horse chestnut, horseradish, licorice,
- meadowsweet - Herbs that may contain salicylates.
- onion - Herbs with Anti-platelet properties.
- panax ginseng, papain, passionflower,
- poplar - Herbs that may contain salicylates.
- prickly ash, quassia, red clover,
- turmeric - Herbs with Anti-platelet properties.
- vitamin E - At appropriate doses, vitamin E has been shown to have virtually the same pharmacological properties as Coumadin
(crystalline warfarin sodium - a prescription anticoagulant). This means that appropriately high doses of Vitamin E may be
substituted for Coumadin. Vitamin E may be considered safer than warfarin, the generic name of Coumadin. Increase the dose
of Vitamin E over a period of weeks. Most people start with 200 IU daily, and eventually get to between 1,200 and 2,400 IU
daily. Do it gradually, and here's a way to tell how it is working - Go in to see your doctor regularly, as you always do,
and continue to have him check your protime with a blood test called the PT-INR (Pro Time - International Normalized Ratio),
as he always does. If you get the protime numbers he wants, he may not care how you got them and they can be mainteaned safely.
The more Vitamin E you take, the stronger the Coumadin's effect. You'll probably get to the point where your protime is too
long, and your doctor may have to reduce the dosage of Coumadin."
- wild carrot, wild lettuce,
- willow bark - Herb that may contain salicylates,
- and others.
Ginger supplement root extract health benefit, side effect,
dosage, medicinal uses for nausea, osteoarthritis, by Ray Sahelian, M.D.
FOR WOUND HEALING, POST SURGERY
The Health Benefits of Bromelain
specially in the stem of the pineapple.
Isolated in the late 1800s,
Uses of bromelain
Bromelain, an enzyme breaks down protein and helps digestation, crucial for muscle production, neurotransmission, and protein-based molecules production.
Absorption of the intact enzyme in the
small intestine leads to its systemic effects of reducing inflammation.
The Health Benefits of Bromelain
1. Swelling & Inflammation
May lower swelling, bruising, pain, and speeds up healing time following surgical procedures.
Double-blind study of over 150 post episiotomies women who received episiotomies. Bromelain for 3 days + post child-birth hugely reduced swelling, inflammation, and pain in 90% women compared to
44% in the placebo group women.
- Topical Applications for Burns
Helps slough off dead tissue from burns beside as an antiinflammatr.
Applied topically to lower swelling and reduce pain.
- Reduced Inflammation After Sports Injuries
- A popular supplements in European countrie and may be as effective as nonsteroidal anti-inflammatory
- Varicose Veins & Hemorrhoids
Reduces the swelling and inflammation and as post ear, nose and throat surgeries.
Indigestion & Heartburn
Specially helpful in combination with amylase ( carbohydrates digestion) and lipase (fat digestion)
and reducing bloating, gas and other irritable bowel syndrome.
May help stomach acidity and alkalinity of the small intestine, bacteria-related diarrhea, inflammatory
bowel disease (IBD).
May promote immunity, boost the immune system hormones, cytokines made in our white blood cells and help relieve some cancer related
lowered immunity side effects.
Bromelain may prevent platelets from
Anti-viral and anti-bacterial properties:
It may be effective for various infectioiu conditions support.